TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development

Table 3 Genotype frequencies of TP53 polymorphism in cases and controls

Patients/controls	Genotype, % (n)			OR1	95%CI	P value
	Arg/Arg	Arg/Pro	Pro/Pro
Cases (n = 642):	56.9 (365)	38.0 (244)	5.1 (33)	2.77	1.59-4.82	0.0001
UC adult (n = 151)	54.3 (82)	38.4 (58)	7.3 (11)	2.50	1.34-4.65	0.0102
CD adult (n = 138)	55.8 (77)	40.6 (56)	3.6 (5)	2.65	1.41-4.98	0.0011
UC pediatric (n = 78)	55.1 (43)	41.0 (32)	3.8 (3)	2.58	1.29-5.17	0.0078
CD pediatric (n = 94)	59.6 (56)	35.1 (33)	5.3 (5)	3.09	1.58-6.07	0.0023
PSC (n = 42)	64.3 (27)	31.0 (13)	4.8 (2)	3.78	1.66-8.63	0.0046
PSC + UC (n = 139)	57.6 (80)	37.4 (52)	5.0 (7)	2.85	1.52-5.35	0.0016
Controls (n = 62)	32.3 (20)	53.2 (33)	14.5 (9)

¹OR is calculated for Arg/Arg vs Arg/Arg + Pro/Pro. CD: Crohn’s disease; UC: Ulcerative colitis; PSC: Primary sclerosing cholangitis.