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Copyright ©The Author(s) 2015.
World J Gastroenterol. Sep 28, 2015; 21(36): 10274-10289
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10274
Table 4 Characteristics and outcomes of rheumatic disease patients with resolved hepatitis B virus infection who experienced viral reactivation during treatment with biological disease-modifying antirheumatic drugs
CaseAge/sexDiseaseAnti-HBs/anti-HBeDMARDsDurationHBV-DNA1 (copies/mL)ALT2 (IU/L)Antiviral therapyOutcomesRef
171/FRAPos./Pos.IFX, MTX, PSL16 moNDNR--[119]
ADM, MTX, PSL11 mo1 × 109674YesDied5
280/FRANDIFX, MTX, PSL48 moNeg.NR--[51]
ETN, MTX, PSL4 moNeg.NR--
ADM, MTX, PSL15 moPos.3NRNoRecovered
373/MASPos./Pos.ETN, PSL14 mo8.8 × 10365YesRecovered[118]
454/FRANeg./Pos.4ETN, MTX, PSL5 mo1.6 × 106199YesRecovered[53]
575/NDRANDETN, MTX, PSLND2.5 × 102NRYesRecovered[49]
660/NDRANDETN, LEFND1.0 × 102NRNoRecovered[49]
749/NDRANDETN, BUC, PSLND2.5 × 107NRYesRecovered[49]
846/NDRANDETN, MTX, TACND5.0 × 103NRYesRecovered[49]
965/NDRANDETN, PSLND1.0 × 105NRYesRecovered[49]
1077/NDRANDTCZ, MTXND1.0 × 102NRNoRecovered[49]
1175/MRANDTCZ, PSL62 moPos.3NRNoRecovered[59]
1255/FRANDIFX25 moNeg.NR--[59]
ETN35 moNeg.NR--
TCZ, MTX PSL62 moPos.3NRNoRecovered
1360/FRANDETN, MTX, PSL665 moPos.3NRNoRecovered[59]
1464/FRAPos./NDRTX, MTX24 mo> 1.0 × 10872YesRecovered[123]
1571/FRANeg./NDRTX, PSL4 wkPos.NRNoRecovered[52]
1664/FRAPos./Neg.RTX, MTX2 yr1.1 × 108605YesRecovered[124]
1778/MRAPos./NDIFX, MTX, PSLNDNDNR--[122]
RTX, PSL27 mo107421YesRecovered
1868/FRANeg./Pos.ABT, MTX10 mo1.1 × 108NRYesRecovered[125]
1972/FRAPos./Pos.ADA, PSL2 yrNeg.NR--[120]
Pos./Pos.ABT, LEF, PSL13 mo7.0 × 1042 × ULNYesRecovered