Recent advances in the molecular diagnostics of gastric cancer

Table 4 Dysregulated microRNAs in hepatocellular carcinoma

Symbol (location)	Materials	Detection methods	Pt	Survival	Relevant clinical factors	Functional analyses	Interacting molecules	In vivo study	Ref.
Early detection
miR-21 (17q23.1)	Circulating	QPCR	103	-	Size, depth	-	-	-	[116]
miR-22 (17p13.3)	Tissue	QPCR	32	-	-	Proliferation, migration, invasion	CD151	-	[117]
miR-29c (1q32.2)	Tissue	QPCR	274	-	-	Proliferation, adhesion, invasion, migration	ITGB1	Yes	[135]
miR-30b (8q24.22)	Tissue	QPCR	21	-	-	Apoptosis	PAI-1	Yes	[134]
miR-106b (7q22.1)	Circulating	QPCR	40	-	Age	-	-	-	[132]
miR-129 (7q32.1)	Gastric juice	QPCR	141	-	-	-	-	-	[118]
miR-141 (12p13.31)	Tissue	QPCR	30	-	-	Proliferation, migration, invasion	HDGF	-	[119]
miR-148a (7p15.2)	Tissue	QPCR	64	-	Size	-	-	-	[127]
miR-181c (19p13.13)	Tissue, circulating	QPCR	30	-	-	-	-	-	[113]
miR-191 (3p21.31)	Tissue, circulating	QPCR	75	-	T, stage	Proliferation, migration, invasion, cell cycle	-	-	[126]
miR-199a-3p (12)	Tissue, circulating	QPCR	180	-	T, N, stage	-	-	-	[115]
miR-223 (Xq12)	Circulating	QPCR	60	-	Helicobacter pylori	-	-	-	[109]
miR-233 (X)	Circulating	QPCR	50	-	Size, differentiation, stage	-	-	-	[130]
Monitoring recurrences
miR-26a (3p22.2)	Tissue	QPCR	40	OS, RFS	N, stage	Proliferation, metastasis	FGF9	Yes	[114]
miR-34b/c (11q23.1)	Noncancerous tissue	Pyrosequencing	129	RFS	Age	-	-	-	[128]
miR-185 (22q11.21)	Tissue	QPCR	126	OS, RFS	N, stage	Proliferation, metastasis	-	Yes	[129]
miR-196a (17q21.32)	Tissue, circulating	QPCR	72	-	-	Migration, invasion	-	-	[110]
miR-200c (12p13.31)	Circulating	QPCR	52	OS, PFS	-	-	-	-	[111]
miR-222 (Xp11.3)	Circulating	QPCR	114	OS, RFS	N, stage	-	-	-	[121]
Prediction of survival
miR-25 (7q22.1)	Tissue, circulating	QPCR	70	OS	N, stage	Proliferation, migration, invasion	TOB1	Yes	[124]
miR-132 (17p13.3)	Tissue	QPCR	79	OS	Lymphovascular invasion, N, stage	-	-	-	[125]
miR-183 (7q32.2)	Tissue	QPCR	80	-	Depth, N, stage	Proliferation, migration, invasion, apoptosis	PDCD4	-	[122]
miR-192 (11q13.1)	Tissue	QPCR	38	-	Sex, vascular invasion, N	Invasion	-	-	[136]
miR-214 (1q24.3)	Tissue	QPCR	80	-	Size, N	Proliferation, migration, invasion	CSF1	-	[131]
miR-630 (15q24.1)	Tissue	QPCR	236	OS	Depth, N, stage	-	-	-	[120]
Prediction of treatment response
miR-17-5p (13q31.3)	Circulating	QPCR	65	OS	Differentiation, stage	-	-	-	[112]
miR-27a (19p13.13)	Circulating	QPCR	82	OS	Chemoresistance	-	-	-	[123]

Pt: Number of patients enrolled in expression analysis; QPCR: Quantitative real-time reverse transcription-polymerase chain reaction; OS: Overall survival; RFS: Recurrence free survival; PFS: Progression free survival; N: Lymph node metastasis.