Copyright
©The Author(s) 2015.
World J Gastroenterol. Sep 14, 2015; 21(34): 9838-9852
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
Symbol (location) | Biological function | Materials | Detection methods | Pt | Survival | Relevant clinical factors | Functional analyses | Interacting molecules | In vivo study | Ref. |
Early detection | ||||||||||
APBA2 (15q11-12) | Neuronal adapter protein interacting with the Alzheimer's disease amyloid precursor protein | Tissue, Circulating | MSP | 90 | OS | Size, differentiation, depth, invasive growth, N, CY, stage | - | - | - | [89] |
GADD45 (1p31.2) | Responding to environmental stresses | Tissue | QPCR, IHC | 138 | OS | Stage | - | - | - | [84] |
OSR1 (2p24.1) | Development of intermediate mesoderm | Tissue | QPCR, IHC | 164 | OS | - | Proliferation, cell cycle, apoptosis | β-catenin, TCF-1 | - | [94] |
RASGRF1 (15q24.2) | Mediator of Ras-GEF signaling pathway | Tissue | QPCR | 130 | - | - | Proliferation, invasion | - | - | [82] |
SPG20 (13q13.3) | Regulating endosomal trafficking and mitochondria function | Tissue, Circulating | IHC, MSP | 119 | OS | - | - | - | - | [95] |
TUSC1 (9p21.2) | Unknown | Tissue | QPCR, IHC | 112 | OS | Age, sex, depth, vascular invasion, N | - | - | - | [92] |
XAF1 (17p13.1) | Inhibitory factor of inhibitor of apoptosis proteins | Tissue, Circulating | QPCR, IHC | 202 | OS, RFS | Size, depth, N, stage, Helicobacter pylori | - | - | - | [85] |
Monitoring recurrences | ||||||||||
DENND2D (1p13.3) | Membrane trafficking protein regulating Rab GTPases | Tissue | QPCR, IHC | 112 | OS, RFS | Age, sex, size, depth, N, stage | - | - | - | [96] |
PDSS2 (6q21) | Synthesize the prenyl side-chain of coenzyme Q | Tissue | QPCR, IHC | 238 | OS, RFS | CA19-9, N | - | - | - | [91] |
Prediction of survival | ||||||||||
PAX5 (9p13) | B-cell lineage specific activator protein that is expressed at early stages of B-cell differentiation | Tissue | QPCR | 187 | OS | Stage | Proliferation, migration, invasion, apoptosis | p53 | Yes | [81] |
PEBP1 (12q24-23) | Inhibitor of Raf1-mediated phosphorylation | Tissue | IHC | 135 | OS | Differentiation, N, stage | - | - | - | [93] |
RASSF5A (1q32.1) | Suppressor of cell growth in response to activated Ras family | Tissue | QPCR, IHC | 132 | OS | Differentiation, depth, N, stage | - | - | - | [90] |
SOCS4 (14q22.1) | suppressor of cytokine signaling | Tissue | QPCR | 50 | OS | Depth, N | - | - | - | [80] |
SOX17 (8q11.23) | Transcription factor involved in the regulation of embryonic development | Circulating | MSP | 73 | OS | Differentiation | - | - | - | [83] |
TCF21 (6q23.2) | Mesoderm specifictranscription factor | Tissue | QPCR, IHC | 200 | OS | Differentiation, depth, N | - | - | - | [97] |
TFF1 (21q22.3) | Protecting the gastrointestinal mucosa | Tissue | QPCR, IHC | 182 | OS | Depth | Invasion | - | - | [87,88] |
Prediction of treatment response | ||||||||||
RPRM (2q23.3) | Regulator of cell cycles in a p53-dependent manner | Tissue | QPCR | 83 | OS | Chemoresistance | Proliferation, apoptosis | - | Yes | [86] |
- Citation: Kanda M, Kodera Y. Recent advances in the molecular diagnostics of gastric cancer. World J Gastroenterol 2015; 21(34): 9838-9852
- URL: https://www.wjgnet.com/1007-9327/full/v21/i34/9838.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i34.9838