Recent advances in the molecular diagnostics of gastric cancer

doi:10.3748/wjg.v21.i34.9838

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Sep 14, 2015 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2015; 21(34): 9838-9852
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838

Table 2 Genes suppressed in gastric cancer

Symbol (location)	Biological function	Materials	Detection methods	Pt	Survival	Relevant clinical factors	Functional analyses	Interacting molecules	In vivo study	Ref.
Early detection
TMEFF2 (2q32.3)	Unknown	Tissue	QPCR, IHC	105	OS	-	Proliferation, apoptosis	SHP-1	Yes	[61]
Monitoring recurrences
BTG1 (12q22)	Regulator of cell growth and differentiation	Tissue	QPCR, IHC	233	OS, RFS	Sex, location, size, N, stage	-	-	-	[59]
eIF3f (11p15.4)	Unknown	Tissue	IHC	195	RFS	CEA, stage	-	-	-	[57]
Prediction of survival
ITIH5 (10p14)	Extracellular matrix stabilization	Tissue	QPCR, IHC	331	OS	Differentiation, N, stage	-	-	-	[60]
JAMA (1q21.2-3)	Regulator of tight junction assembly in epithelia	Tissue	IHC	167	OS	Size, lymphovascular invasion, N, stage	Migration, invasion	-	-	[58]
SEMA3A (7p12.1)	Neuronal pattern development	Tissue	IHC	128	OS	Differentiation, depth, N, stage	Proliferation, migration	-	-	[62]
STUB1 (16p13.3)	Ubiquitin ligase/cochaperone	Tissue	IHC	493	OS	Size, depth, N, stage	Proliferation	NF-κB, IL-8	Yes	[56]

Pt: Number of patients enrolled in expression analysis; IHC: Immunohistochemistry; QPCR: Quantitative real-time reverse transcription-polymerase chain reaction; OS: Overall survival; RFS: Recurrence free survival; N: Lymph node metastasis.

Citation: Kanda M, Kodera Y. Recent advances in the molecular diagnostics of gastric cancer. World J Gastroenterol 2015; 21(34): 9838-9852
URL: https://www.wjgnet.com/1007-9327/full/v21/i34/9838.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i34.9838