Efficacy of hepatic resection vs transarterial chemoembolization for solitary huge hepatocellular carcinoma

Table 4 Prognostic factors predicting overall survival in propensity score-matched patients with solitary huge hepatocellular carcinoma undergoing hepatic resection or transarterial chemoembolization

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P-value	HR	95%CI	P-value
Age (yr)	0.988	0.970-1.007	0.220
Gender (M/F)	1.459	0.357-5.962	0.599
Tumor size (cm)	1.054	0.973-1.141	0.197
HBsAg (+/-)	1.391	0.340-5.685	0.646
Child-Pugh class (A/B)	0.919	0.289-2.921	0.887
Cirrhosis (present/absent)	1.207	0.621-1.611	0.579
AFP (≥ 400/< 400 ng/mL)	1.721	1.097-2.347	0.018	1.997	1.259-3.166	0.003
Total bilirubin (μmol/L)	1.025	0.994-1.057	0.116
ALT (U/L)	1.004	1.000-1.009	0.052
AST (U/L)	1.003	0.997-1.008	0.322
Prothrombin time (s)	1.052	0.922-1.201	0.453
Albumin (g/L)	1.010	0.969-1.053	0.653
Platelet count (109/L)	0.998	0.995-1.001	0.190
Vascular invasion (present/absent)	2.335	1.057-5.159	0.036	2.347	1.051-5.242	0.037
Treatment modality (TACE/hepatic resection)	2.343	1.468-3.741	< 0.001	2.492	1.550-4.006	< 0.001

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; AFP: Alpha-fetoprotein; HR: Hazard ratio; TACE: Transarterial chemoembolization.