Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer

Figure 4 Association of the rs2736100 polymorphism with hTERT mRNA expression and telomere length in intestinal- and diffuse-type gastric cancers. A: The telomere length shortened in diffuse-type gastric cancer (P = 0.0251), but hTERT mRNA expression was not associated with histologic differentiation of gastric cancers (P = 0.1485); B: When we combined C/A and A/A genotypes, telomere length and hTERT mRNA levels were markedly increased in those with the C/C genotype in intestinal-type gastric cancer (P = 0.0069 and P = 0.0204, respectively); C: The rs2736100 polymorphism was not associated with hTERT expression and telomere length in diffuse-type gastric cancers (P = 0.1414 and P = 0.2298, respectively). hTERT: Human telomerase reverse transcriptase; INT: Intestinal-type gastric cancer, DIF: Diffuse-type gastric cancer.