Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma

Table 1 Targeting hepatocellular carcinoma related gene products

No.	Approach	Molecular target	In vivo model	Effects	Ref.
1	Targeting molecules more relevant for HCC than normal liver	Integrins	Mouse genetically induced HCC	Reduction HCC cell proliferation	20
2	Targeting molecules overexpressed in HCC tissue	ECT2	Mouse xenograft HCC	Reduction HCC cell proliferation	21
3	Targeting molecules overexpressed in HCC tissue	CDK9	Mouse orthotopic HCC	Reduction HCC cell proliferation	22
4	Targeting molecules overexpressed in HCC tissue	ISG15	Mouse xenograft HCC	Reduction HCC cell proliferation	23
5	Targeting of genes causing drug resistance	Mapk14	Mouse genetically induced HCC	Increased sorafenib sensitivity	24
6	Targeting of genes causing drug resistance	Aurora-A	Mouse xenograft HCC	Increased adriamycin and cisplatin sensitivity	25

HCC: Hepatocellular carcinoma.