Transient elastography improves detection of liver cirrhosis compared to routine screening tests

Table 4 Comparison of transient elastography with clinical and biochemical parameters

	≥ 13 kPa(n = 161)	≥ 27.5 kPa1(n = 94)	≥ 54 kPa1(n = 48)	≥ 27.5kPa vs< 27.5 kPaP value	≥ 54 kPa vs< 54 kPaP value	≥ 54 kPa vs27.5-54 kPaP value
Age, yr	60 ± 14	56 ± 13	55 ± 13	NS	NS	NS
BMI, kg/m²	26.2 ± 3.7	25.5 ± 4.0	24.8 ± 3.7	NS	0.05	NS
Bilirubin, mg/dL	1.1 ± 1.0	3.2 ± 5.6	4.4 ± 6.9	0.0001	0.007	0.04
Albumin, g/dL	3.9 ± 0.4	3.4 ± 0.7	3.2 ± 0.7	0.0001	0.0001	0.02
Immunoglobulins, g/dL	1.6 ± 0.7	2.0 ± 0.7	2.1 ± 0.8	0.02	0.007	0.03
AST, U/L	79 ± 49	102 ± 71	115 ± 83	0.02	0.015	0.07
ALT, U/L	79 ± 56	71 ± 51	69 ± 54	NS	NS	NS
AFP, μg/L2	7.6	7.7	7.8	NS	NS	NS
Platelets, 1000/μL	145 ± 68	144 ± 82	151 ± 77	NS	NS	NS
Prothrombin time, %	88 ± 13	76 ± 19	70 ± 18	0.0001	0.0001	0.02
APRI-Score3	2.4 ± 1.8	3.6 ± 3.1	4.3 ± 3.6	0.03	NS	NS
Platelets < 150.000/μL, %	59.7	60.6	56.3	NS	NS	NS
Ultrasound cirrhosis, %	73.1	88.9	93.6	0.02	0.01	NS
Splenomegaly, %	57.8	71.4	72.3	0.09	NS	NS
Ascites, %	16.4	35.5	52.1	0.01	0.0001	0.01
Cutaneous liver signs, %	43.3	55.3	63.2	NS	0.09	NS

¹Cut-off values in accordance to Foucher et al[30];

²AFP is given as median value;

³APRI-Score was only applied to patients with chronic viral hepatitis. NS: Not significant.