Transient elastography improves detection of liver cirrhosis compared to routine screening tests

Table 2 Sensitivity, specificity, positive and negative predictive value of the different non-invasive examinations for detection of liver cirrhosis

	All					Viral hepatitis1
	Sensitivity	Specificity	PPV	NPV	P value3	Sensitivity	Specificity	PPV	NPV	P value3
Liver stiffness ≥ 13 kPa	90.4	51.4	75.2	76.7		91.3	44.4	82.5	64.0
Ultrasound2	80.1	82.4	88.7	70.6	0.02	96.6	61.2	81.4	90.9	0.04
Platelets < 150.000/μL	58.0	80.2	83.3	52.8	0.03	63.1	72.2	86.7	40.6	0.05
Cutaneous liver signs2	45.1	72.1	70.4	47.2	0.0001	42.7	64.7	77.4	28.6	0.01
APRI-Score ≥ 2	NA	NA	NA	NA	NA	56.1	63.3	87.7	24.1

¹n = 139; only patients with chronic hepatitis B, C and D were included;

²According to the definitions in the patients and methods section; available for 257 patients;

³For comparison of sensitivities with liver stiffness as reference. NA: Not applicable; PPV: Positive predictive value; NPV: Negative predictive value.