Prognosis after resection for hepatitis B virus-associated intrahepatic cholangiocarcinoma

Table 4 Univariate and multivariate analyses of prognostic factors for disease-free survival in hepatitis B virus-associated intrahepatic cholangiocarcinoma patients included in this study

Variable	n	Univariate analysis			Multivariateanalyses
		1-yr	5-yr	P value	HR	95%CI	P value
Gender				0.312	NA	NA	NA
Female	19	50%	0%
Male	66	32%	4%
Age				0.853	NA	NA	NA
≤ 60	59	33%	1%
> 60	26	42%	5%
Capsule formation				0.970	NA	NA	NA
Yes	32	40%	7%
No	53	33%	0%
Cirrhosis				0.003	1.919	1.153-3.192	0.012
Yes	48	22%	0%
No	37	52%	5%
Child-Pugh class				0.237	NA	NA	NA
A	76	50%	20%
B	9	27%	0%
AFP (ng/mL)				0.648	NA	NA	NA
≤ 20	48	32%	3%
> 20	37	40%	2%
CA19-9 (U/mL)				0.189	NA	NA	NA
≤ 37	55	39%	3%
> 37	30	29%	2%
Gross type				0.917	NA	NA	NA
MF	63	37%	3%
PI + IG	22	30%	0%
Differentiation				0.076	NA	NA	NA
Well or Moderate	63	42%	3%
Poor	22	18%	0%
Tumor number				< 0.001	NA	NA	NA
Single	60	48%	3%
Multiple	25	5%	0%
Tumor size				0.091	NA	NA	NA
< 5 cm	43	44%	1%
≥ 5 cm	42	27%	5%
LN metastasis				< 0.001	NA	NA	NA
Yes	11	0%	0%
No	74	40%	3%
Vascular invasion					3.779	1.601-8.923	0.020
Yes	11
No	74
TNM classification				< 0.001	NA	NA	NA
Stage I or II	61	0%	0%
Stage III or IV	24	51%	20%
Width of resection margin				< 0.001	NA	NA	NA
< 1 cm	37	49%	4%
≥ 1 cm	48	0%	0%
Surgical procedure				0.391	NA	NA	NA
Major hepatectomy	40	41%	2%
Minor hepatectomy	45	31%	3%

AFP: Alpha-fetoprotein; CA19-9: Carbohydrate antigen 19-9; MF: Mass-forming; PI: Periductal infiltrating; IG: Intraductal growth; TNM: Tumor-node-metastasis; NA: Not available; HR: Hazard ratio; LN: Lymph node.