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Copyright ©The Author(s) 2015.
World J Gastroenterol. Jul 28, 2015; 21(28): 8478-8491
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8478
Table 2 Select current molecular inhibitors under investigation as standalone or combination therapies for treatment of hepatocellular carcinoma
Drug nameMethod of actionClinical phase
LenvatinibVEGFR, PDGFR, FGFR, RET and c-Kit inhibitorIII, ongoing as 1st line
BrivanibVEGFR2 and FGFR tyrosine kinasesIII, negative as 1st line
EverolimusmTOR inhibitorIII, negative
Tivantinibc-MET inhibitorIII, ongoing as 2nd line
LinifanibRTK, VEGF and PDGF inhibitorIII, negative as 1st line
Sorafenib (as adjuvant)Raf/MEK/ERK inhibitorIII, negative
RamucirumabVEGFR2II and III, negative
Foretinibc-MET inhibitorII
RefametinibMEK1/2 inhibitorII
MapatumumabTRAIL-receptor (death receptor 4)II
SelumetinibMAPK/ERK inhibitorII
ErlotinibEGFR tyrosine kinase inhibitorII
LapatinibEGFR and HER2/neu inhibitorII
CabozantinibVEGFR2, c-MET, RET, KIT, FLT4, AXLIII
MSC2156119Jc-MET/HGFIb/II
LenalidomideImmunomodulatoryII