TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury

Table 7 HMGB1, NF-κB, MyD88, and TRIF mRNA expression in ileum from all groups (mean ± SD)

Group (n = 6)	HMGB1	NF-κB	MyD88	TRIF
Sham	1.04 ± 0.19	1.03 ± 0.21	1.01 ± 0.10	1.01 ± 0.11
Control	2.67 ± 0.30a	2.04 ± 0.29a	2.55 ± 0.16a	3.05 ± 0.10a
Anti-HMGB1	1.89 ± 0.18ab	1.42 ± 0.23ab	2.37 ± 0.08ab	2.90 ± 0.13ab
Anti-MyD88	2.35 ± 0.31abc	1.77 ± 0.18abc	2.30 ± 0.16ab	3.04 ± 0.13ac
Anti-TRIF	2.29 ± 0.28abc	1.70 ± 0.13abc	2.53 ± 0.07acd	2.85 ± 0.12abd

^aP < 0.05 vs sham group;

^bP < 0.05 vs control group;

^cP < 0.05 vs anti-HMGB1 group;

^dP < 0.05 vs anti-MyD88 group. HMGBI: High-mobility group protein 1; MyD88: Myeloid differentiation gene 88; NF-κB: Nuclear factor-κB; TRIF: Translocating-chain-associating membrane protein.