TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury

doi:10.3748/wjg.v21.i27.8314

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2015; 21(27): 8314-8325
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8314

Table 6 HMGB1and NF-κB mRNA expression in lungs from all groups (mean ± SD)

Group (n = 6)	HMGB1	NF-κB
Sham	1.04 ± 0.19	1.03 ± 0.21
Control	2.67 ± 0.30^a	2.04 ± 0.29^a
Anti-HMGB1	1.89 ± 0.18^a^b	1.42 ± 0.23^a^b
Anti-MyD88	2.35 ± 0.31^a^b^c	1.77 ± 0.18^a^b^c
Anti-TRIF	2.29 ± 0.28^a^b^c	1.70 ± 0.13^a^b^c

^aP < 0.05 vs sham group;

^bP < 0.05 vs control group;

^cP < 0.05 vs anti-HMGB1 group. HMGBI: High-mobility group protein 1; MyD88: Myeloid differentiation gene 88; NF-κB: Nuclear factor-κB; TRIF: Translocating-chain-associating membrane protein.

Citation: Wang J, He GZ, Wang YK, Zhu QK, Chen W, Guo T. TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury. World J Gastroenterol 2015; 21(27): 8314-8325
URL: https://www.wjgnet.com/1007-9327/full/v21/i27/8314.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i27.8314