Changes in gene expression in liver tissue from patients with fulminant hepatitis E

Table 3 Results of Gene Ontology analysis (biological processes) for gene entities differentially expressed in liver tissue from fulminant hepatitis E as compared to normal liver, but not in that from fulminant hepatitis B as compared to normal liver

Gene Ontology term	P value
Immune system process1	1.67E-11
Immune response1	4.81E-09
Regulation of immune system process1	5.06E-08
Positive regulation of immune system process1	2.72E-06
Defense response	1.04E-05
Response to wounding	1.90E-05
Signaling	7.78E-05
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains1	2.40E-04
Adaptive immune response1	2.40E-04
Response to stimulus	3.53E-04
Regulation of cell activation	4.65E-04
Inflammatory response1	6.89E-04
Cell adhesion	0.0010
Biological adhesion	0.0010
Positive regulation of immune response1	0.0015
Cell activation	0.0018
Signal transduction	0.0019
Regulation of leukocyte activation1	0.0020
Activation of immune response1	0.0021
Oxidation reduction	0.0021
B cell mediated immunity1	0.0023
Leukocyte mediated immunity1	0.0026
Positive regulation of response to stimulus	0.0027
Regulation of locomotion	0.0028
Regulation of immune response1	0.0030
Phospholipid efflux	0.0032
Lymphocyte mediated immunity1	0.0032
Regulation of cell migration1	0.0048
Regulation of cell motility1	0.0048
Response to stress	0.0050
Regulation of lymphocyte activation1	0.0056
Regulation of cellular component movement	0.0064
Signal transmission	0.0067
Immunoglobulin mediated immune response1	0.0067
Signaling process	0.0067
Small molecule metabolic process	0.0083
Cholesterol efflux	0.0124
Immune effector process1	0.0154
Negative regulation of apoptosis	0.0161
Positive regulation of cell activation	0.0176
Positive regulation of leukocyte activation1	0.0176
Regulation of response to stimulus	0.0177
Negative regulation of cell death	0.0179
Negative regulation of programmed cell death	0.0179
Regulation of lipid metabolic process	0.0180
Signaling pathway	0.0206
Acute inflammatory response1	0.0241
Phospholipid transport	0.0257
Regulation of fatty acid metabolic process	0.0273
Alcohol metabolic process	0.0282
Cholesterol transport	0.0310
Sterol transport	0.0472

¹These pathways are related to immune responses.