Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats

Figure 4 Ezetimibe increases autophagosome formation and autophagic flux in hepatocytes. Electron microscopy of hepatocytes demonstrated ezetimibe-induced autophagy (A). Representative blot (B) and quantitative analysis (C) expressed as LC3-II (14 kDa)/LC3-I (16 kDa) followed by sample/control (mean ± SE). ^aP < 0.05, ^bP < 0.01, vs control in the absence of PA and BAF; ^cP < 0.05, PA vs PA + Ez in the absence of BAF; ^dP < 0.01, vs control in the absence of PA but in the presence of BAF. ^fP < 0.01, PA vs PA + Ez in the presence of BAF. BAF: Bafilomycin A1; Con: Control; Ez: Ezetimibe; PA: Palmitic acid.