TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer

Figure 3 Toll-like receptor 2 (A) and toll-like receptor 4 (B) mRNA relative quantification, using tumor tissue samples from a wild-genotype colorectal cancer group as a calibrator, compared to those with at least one polymorphic allele. Using Wilcoxon’s signed rank test, a statistically significant difference was found for the gene expression of TLR2 (^aP = 0.037), but not for TLR4 (P = 1.000). The reference genes ACTB and GAPDH were used as endogenous controls. CRC: Colorectal cancer.