Primary combined hepatocellular-cholangiocellular sarcoma: An unusual case

Figure 3 Immunohistochemical expression of the carcinosarcoma. A: Pan-cytokeratin staining showed diffuse and strong signals for HCC cells; B: HCC elements showed various staining pattern for cytokeratin 19 with intermediate hepatobiliary cell-like tumor cells (arrows); C: Carcinomatous elements were strongly positive for epithelial membrane antigen; D: Spindle cells and chondrosarcoma cells (area fenced by dotted line) were positive for epithelial membrane antigen; E: Carcinoma cells were positive for CD117, as were ductular reactions (arrows) and undifferentiated cells (arrows, inset); F: Sarcoma cells were positive for CD117; G: Sarcomatous elements strongly stained for vimentin; H: Diffuse staining for smooth muscle actin in sarcoma cells; All magnifications are × 100.