Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats

doi:10.3748/wjg.v21.i23.7155

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2015; 21(23): 7155-7164
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7155

Table 2 Bile duct ligation-induced pathways reversed by bicyclol treatment

Pathway	Relate genes	P value
ECM-receptor interaction	Lamc1, Col4a2, Spp1, Col3a1, Col1a1, Lamb2, Col4a1, Agrn, Itgb4, Thbs1	0.0000003
Fatty acid metabolism	Acadsb, Ehhadh, Cyp4a3/4a2, Acsl1, Cpt1a, Acaa1b	0.00012
PPAR signaling pathway	Ehhadh, Scd, Cyp4a3/4a2, Acsl1, Cpt1a, Acaa1b	0.00017
Focal adhesion	Lamc1, Col4a2, Spp1, Col3a1, Col1a1, Lamb2, Col4a1, Itgb4, Thbs1	0.00192
Biosynthesis of unsaturated fatty acids	Scd1, Acot2, Scd, Acaa1b	0.00267
Oxidation reduction	Acadsb, Dhcr24, Gpx3, Scd, Rdh2, Akr1b1, Cyp4a3/4a2, Steap4, Cyp3a23/3a1, Loxl1, Ehhadh, Scd1, Aldh1a2, Hsd17b6	0.00575
Integrin signaling pathway	Lamc1, Col4a2, Col3a1, Col1a1, Lamb2, Col4a1, Itgb4, Col12a1	0.00793
Retinol metabolism	Cyp3a23/3a1, Ugt2a3, Cyp4a3/4a2, Aldh1a2	0.03196

ECM: Extracellular matrix.

Citation: Zhen YZ, Li NR, He HW, Zhao SS, Zhang GL, Hao XF, Shao RG. Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats. World J Gastroenterol 2015; 21(23): 7155-7164
URL: https://www.wjgnet.com/1007-9327/full/v21/i23/7155.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i23.7155