Standard chemotherapy with cetuximab for treatment of colorectal cancer

Table 2 Adverse events (grade 3 and 4)

Study	Neutropenia		Nausea and vomiting		Skin toxicity/rash		Rash		Diarrhea
	Control group	Cetuximab group	Control group	Cetuximab group	Control group	Cetuximab group	Control group	Cetuximab group	Control group	Cetuximab group
Borner et al[27]	3	0	6	10	0	16	0	8	16	22
Bokemeyer et al[25]	57	51	NA	NA	1	30	1	19	12	14
Van Cutsem et al[21]	150	169	30	28	1	117	0	49	63	94
Maughan et al[17]	NA	NA	NA	NA	14	114	NA	NA	NA	NA
Tveit et al[22]	47	95	3	14	1	51	1	51	10	33
Alberts et al[26]	89	110	59	70	NA	NA	3	186	83	148
Huang et al[24]	15	3	0	18	NA	NA	0	11	15	6
Ye et al[23]	6	8	3	3	1	2	2	9	3	4

GI: Gastrointestinal toxic effects; NA: Not available.