Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn’s disease

Table 7 Stability of antiphospholipid antibodies marker status over time in inflammatory bowel diseases patients with at least 2 samples during the disease course n (%)

APLA marker	CD (n = 198)	UC (n = 103)
Anti-β2-GPI IgG
Stable negative	194 (98.0)	97 (94.2)
Stable positive	1 (0.5)	2 (1.9)
Neg. to pos.	0 (0.0)	3 (2.9)
Pos. to neg.	3 (1.5)	1 (1.0)
Anti-β2-GPI IgM
Stable negative	186 (94.0)	94 (91.3)
Stable positive	4 (2.0)	3 (2.9)
Neg. to pos.	6 (3.0)	5 (4.9)
Pos. to neg.	2 (1.0)	1 (0.9)
Anti-β2-GPI IgA
Stable negative	190 (96.0)	93 (90.3)
Stable positive	1 (0.5)	4 (3.9)
Neg. to pos.	3 (1.5)	5 (4.9)
Pos. to neg.	4 (2.0)	1 (0.9)
ACA IgG
Stable negative	139 (70.2)	95 (92.2)
Stable positive	3 (1.5)	1 (1.0)
Neg. to pos.	42 (21.2)	6 (5.8)
Pos. to neg.	14 (7.1)	1 (1.0)
ACA IgM
Stable negative	173 (87.4)	95 (92.2)
Stable positive	3 (1.5)	1 (1.0)
Neg. to pos.	18 (9.1)	7 (6.8)
Pos. to neg.	4 (2.0)	0 (0.0)
ACA IgA
Stable negative	73 (36.9)	78 (75.7)
Stable positive	13 (6.6)	0 (0.0)
Neg. to pos.	93 (46.9)	24 (23.3)
Pos. to neg.	19 (9.6)	1 (1.0)

Anti-PS/PT measurements were only preformed on the first available serum samples of the patients. APLA: Antiphospholipid antibodies; β2-GPI: Beta2-glycoprotein-I; ACA: Anti-cardiolipin antibody; PS/PT: Phosphatidylserine/prothrombin complex; CD: Crohn’s disease; UC: Ulcerative colitis.