Clinical impact of preoperative acute pancreatitis in patients who undergo pancreaticoduodenectomy for periampullary tumors

Table 4 Risk factors influencing pancreatic fistula after pancreaticoduodenectomy by univariate and multivariate logistic regression analyses

Parameter	Univariate1		Multivariate1
	OR (95%CI)	P value	OR (95%CI)	P value
Age (≥ 70 yr vs < 70 yr)	0.74 (0.24-2.30)	0.738
Sex (male vs female)	0.57 (0.23-1.43)	0.228
Weight loss (yes vs no)	1.10 (0.48-2.51)	0.821
Preoperative jaundice (yes vs no)	1.55 (0.64-3.76)	0.334
Acute pancreatitis (yes vs no)	3.14 (1.28-7.67)	0.012	2.91 (1.10-7.68)	0.032
Blood transfusion (yes vs no)	1.23 (0.53-2.81)	0.632
Comorbid disease (yes vs no)	1.36 (0.58-3.19)	0.485
Preoperative biliary drainage (yes vs no)	4.97 (1.70-14.54)	0.003	3.40 (1.05-10.99)	0.041
Intraoperative blood transfusion (yes vs no)	2.28 (0.99-5.24)	0.052	2.69 (1.08-6.71)	0.034
Histopathologic diagnosis		0.090		NS
Pancreatic carcinoma	1.0
Ampullary carcinoma	1.86 (0.53-6.53)	0.333
Duodenal carcinoma	2.54 (0.83-7.73)	0.022
Distal bile duct carcinoma	3.83 (1.28-11.45)	0.016
Pancreatic texture (soft vs hard)	9.29 (1.22-70.68)	0.031	9.82 (1.22-79.31)	0.032
Pancreatic duct (< 3 mm vs≥ 3 mm)	2.22 (0.85-5.82)	0.105

¹Logistic regression. NS: Not significant.