Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population

doi:10.3748/wjg.v21.i22.6898

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World Journal of Gastroenterology

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World J Gastroenterol. Jun 14, 2015; 21(22): 6898-6904
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6898

Table 3 Logistic regression analysis of the association between the single-nucleotide polymorphisms and esophageal cancer risk n (%)

SNP	Model	Genotype	Cases	Controls	OR¹ (95%CI)	P value	AIC	BIC
rs1321311	Codominant	G/G	226 (64.2)	226 (72.9)	1	0.004	670.6	693.0
		G/T	111 (31.5)	81 (26.1)	1.27 (0.84-1.93)
		T/T	15 (4.3)	3 (1.0)	8.06 (1.96-33.07)
	Dominant	G/G	226 (64.2)	226 (72.9)	1	0.066	676.1	694.1
	Dominant	G/T-T/T	126 (35.8)	84 (27.1)	1.46 (0.97-2.19)	0.066	676.1	694.1
	Recessive	G/G-G/T	337 (95.7)	307 (99.0)	1	0.002	669.9	687.8
	Recessive	T/T	15 (4.3)	3 (1.0)	7.51 (1.84-30.66)	0.002	669.9	687.8
rs4444235	Codominant	T/T	76 (23.5)	100 (32.4)	1	0.046	651.8	674.0
		C/T	174 (53.7)	149 (48.2)	1.69 (1.08-2.65)
		C/C	74 (22.8)	60 (19.4)	1.75 (1.01-3.02)
	Dominant	T/T	76 (23.5)	100 (32.4)	1	0.013	649.8	667.6
	Dominant	C/T-C/C	248 (76.5)	209 (67.6)	1.71 (1.12-2.62)	0.013	649.8	667.6
	Recessive	T/T-C/T	250 (77.2)	249 (80.6)	1	0.350	655.0	672.8
	Recessive	C/C	74 (22.8)	60 (19.4)	1.25 (0.79-1.98)	0.350	655.0	672.8
rs6687758	Codominant	A/A	212 (59.2)	183 (59.2)	1	0.066	679.0	701.5
		G/A	118 (33.0)	115 (37.2)	0.86 (0.58-1.28)
		G/G	28 (7.8)	11 (3.6)	2.40 (1.01-5.74)
	Dominant	A/A	212 (59.2)	183 (59.2)	1	0.950	682.4	700.4
	Dominant	G/A-G/G	146 (40.8)	126 (40.8)	0.99 (0.68-1.44)	0.950	682.4	700.4
	Recessive	A/A-G/A	330 (92.2)	298 (96.4)	1	0.027	677.5	695.5
	Recessive	G/G	28 (7.8)	11 (3.6)	2.54 (1.08-6.00)	0.027	677.5	695.5
rs3802842	Codominant	A/A	119 (33.4)	101 (32.8)	1	0.033	681.0	703.5
		C/A	174 (48.9)	136 (44.2)	0.91 (0.60-1.40)
		C/C	63 (17.7)	71 (23.1)	0.52 (0.31-0.88)
	Dominant	A/A	119 (33.4)	101 (32.8)	1	0.190	684.1	702.1
	Dominant	C/A-C/C	237 (66.6)	207 (67.2)	0.77 (0.52-1.14)	0.190	684.1	702.1
	Recessive	A/A-C/A	293 (82.3)	237 (77.0)	1	0.010	679.2	697.1
	Recessive	C/C	63 (17.7)	71 (23.1)	0.55 (0.34-0.87)	0.010	679.2	697.1
rs4939827	Codominant	C/C	228 (63.3)	179 (57.7)	1	0.110	687.0	709.5
		C/T	117 (32.5)	108 (34.8)	0.68 (0.46-1.02)
		T/T	15 (4.2)	23 (7.4)	0.58 (0.26-1.33)
	Dominant	C/C	228 (63.3)	179 (57.7)	1	0.038	685.1	703.2
	Dominant	C/T-T/T	132 (36.7)	131 (42.3)	0.67 (0.46-0.98)	0.038	685.1	703.2
	Recessive	C/C-C/T	345 (95.8)	287 (92.6)	1	0.330	688.5	706.5
	Recessive	T/T	15 (4.2)	23 (7.4)	0.67 (0.30-1.50)	0.330	688.5	706.5

¹Adjusted by sex and age. AIC: Akaike’s information criterion; BIC: Bayesian information criterion; SNP: Single-nucleotide polymorphism.

Citation: Geng TT, Xun XJ, Li S, Feng T, Wang LP, Jin TB, Hou P. Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population. World J Gastroenterol 2015; 21(22): 6898-6904
URL: https://www.wjgnet.com/1007-9327/full/v21/i22/6898.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i22.6898