Platelet to lymphocyte ratio as a novel prognostic tool for gallbladder carcinoma

Table 3 Univariate analysis of factors associated with overall survival of gallbladder carcinoma patients

As binary data			As quantitative/ordinal data
Variable	P value	HR (95%CI)	Variable	P value	HR (95%CI)
Age > 60 yr	0.574	1.078 (0.829-1.403)	Age (per 1 yr increase)	0.456	1.004 (0.993-1.016)
Women vs men	0.829	1.030 (0.788-1.345)
Gallstone (yes vs no)	0.309	1.137 (0.887-1.458)
Diabetes (yes vs no)	0.420	1.194 (0.777-1.835)
Hypertension (yes vs no)	0.997	1.001 (0.725-1.382)
CEA > 3.4 ng/mL	0.012	1.620 (1.114-2.355)	CEA (per 1 ng/mL increase)	0.071	1.005 (1.000-1.011)
AFP > 20 ng/mL	0.420	0.663 (0.244-1.801)	AFP (per 1 ng/mL increase)	0.296	0.997 (0.990-1.003)
CA-125 > 35.0 U/mL	0.002	1.813 (1.236-2.658)	CA-125 (per 10 U/mL increase)	0.027	1.005 (1.001-1.009)
CA-199 > 39.0 U/mL	0.002	1.930 (1.284-2.903)	CA-199 (per 10 U/mL increase)	0.028	1.001 (1.000-1.002)
PLT > 300 × 109/L	0.956	1.013 (0.647-1.594)	PLT (per 109/L increase)	0.053	1.001 (1.000-1.003)
Lymphocytes	0.243	1.173 (0.897-1.534)	Lymphocytes (per 109/L increase)	0.064	0.801 (0.633-1.013)
< 1.5 × 109/L
PLR ≥ 117.7	< 0.001	1.644 (1.246-2.169)	PLR (per 10 increase)	0.023	1.007 (1.001-1.013)
TNM IV vs I-III	< 0.001	1.692 (1.260-2.274)	TNM (per 1 stage increase)	< 0.001	1.377 (1.213-1.564)
Differentiation (low vs moderate/high)	< 0.001	1.563 (1.217-2.006)	Differentiation (per 1 grade increase)	< 0.001	1.523 (1.256-1.845)

HR: Hazard ratio; CI: Confidence interval.