SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis

Figure 1 Serum-and-glucocorticoid-inducible-kinase-1 expression was increased in intestinal epithelial cells of patients with Crohn’s disease. Immunohistochemistry of serum-and-glucocorticoid-inducible-kinase-1 (SGK1) in samples from patients with active Crohn’s disease (CD) and normal controls. Weak staining of SGK1 was detected in the samples from normal controls, while strong staining of SGK1 was observed in samples from patients with active CD. The CD group (n = 8) had 4 males and 4 females. The normal control group (n = 8) had 4 males and 4 females. ^aP < 0.05 vs normal controls. SGK1: Serum-and-glucocorticoid-inducible-kinase-1.