Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: A case-control study in Korea

Table 5 Interaction between diabetes mellitus and hepatitis B virus infection for intrahepatic cholangiocarcinoma: logistic regression analysis with adjusted odds ratio

Interaction variables		n	βCoefficient (± SE)	P value	AOR1 (95%CI)	S (95%CI)
DM	HBV
Negative	Negative	194			1
Positive	Negative	27	1.670 (0.51)	0.001	5.3 (2.0-14.3)
Negative	Positive	19	1.718 (0.58)	0.003	5.6 (1.8-17.4)
Positive	Positive	9	3.120 (1.15)	0.006	22.7 (2.4-214.1)	2.44 (1.30-4.58)
Complicated DM	HBV
Negative	Negative	211			1
Positive	Negative	10	1.660 (0.77)	0.031	5.3 (1.2-23.8)
Negative	Positive	20	1.528 (0.56)	0.006	4.6 (1.5-13.7)
Positive	Positive	8	3.782 (1.51)	0.012	43.9 (2.3-849.5)	5.45 (3.16-9.42)

¹AOR: Odds ratio adjusted for the other significant risk factors for intrahepatic cholangiocarcinoma. DM: Diabetes mellitus; HBV: Hepatitis B virus; AOR: Adjusted odds ratio; S: Synergism index.