Management of hepatitis C in patients with chronic kidney disease

Table 2 Treatment regimens for hepatitis C virus infection in chronic kidney patients

Stage of CKD	Estimated GFR	Target dosage of ribavirin	Dosage of Interferon
1	≥ 90	800 to 1200 mg qd1	PEG-IFN α2a 180 μg qw or PEG-IFN α2b 1.5 μg/kg qw
2	60 to 89	600 to 800 mg qd1
3	30 to 59	400 to 600 mg qd1
4	15 to 29	200 mg qd	PEG-IFN α2a 135 μg qwor PEG-IFN α2b 1.0 μg/kg qw
5	< 15 or HD	Titrated according to patient tolerability2

¹Divided in two doses;

²See text for details. GFR: Glomerular filtration rate expressed in mL/min per 1.73 m²; qd: Once a day; PEG-IFN: Pegylated interferon; qw: Once a week; HD: Hemodyalisis.