Novel immunological and nutritional-based prognostic index for gastric cancer

Table 3 Univariate and multivariate analyses of prognostic factors in gastric cancer patients

Variable	UnivariateP value	Multivariate
		HR	95%CI	P value
Age (yr)	0.041			0.004
≤ 65		1
> 65		2.323	1.299-4.156
Sex	0.299
Male
Female
Resectability	< 0.001			0.018
R0		1
R1, R2		2.062	1.133-3.759
Tumor depth	< 0.001
T1, T2
T3, T4
Lymph node	< 0.001
N0
N1-3
Distant metastasis	< 0.001			< 0.001
M0		1
M1		10.505	6.540-16.874
Pathological stage
I		1
II	< 0.001	2.552	1.591-4.095	< 0.001
III	< 0.001	4.695	3.053-7.220	< 0.001
IV	< 0.001	10.505	6.540-16.874	< 0.001
WBC	0.002
≤ 11 × 109/L
> 11 × 109/L
ALB	< 0.001
≥ 35 g/L
< 35 g/L
PLT	< 0.001
≤ 300 × 109/L
> 300 × 109/L
CEA	< 0.001			0.004
≤ 5 ng/mL		1
> 5 ng/mL		1.457	1.126-1.883
Histological type	< 0.001
Well
Poor
Blood loss	< 0.001
≤ 400 mL
> 400 mL
Operative time	0.067
≤ 4 h
> 4 h
Postoperative chemotherapy	0.479
Absent
Present
Postoperative complications	< 0.001			0.002
Absent		1
Present		1.516	1.164-1.974
PNI	< 0.001			< 0.001
1		1
2		1.668	1.368-2.035
NLR	< 0.001			0.656
1		1
2		1.056	0.830-1.343
PLR	< 0.001			0.113
1		1
2		1.190	0.960-1.475
Propensity score				0.398

WBC: White blood cell; ALB: Albumin; PLT: Platelet; CEA: Carcino-embryonic antigen; PNI: Prognostic nutritional index; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; HR: Hazard ratio.