Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence

Table 2 Characteristics of patients stratified according to recurrence status

Parameter	Recurrence	No recurrence	P value
	(n = 76)	(n = 96)
Sex, male/female	63/13	76/20	0.537
Age, yr	54.6 ± 10.3	52.7 ± 10.6	0.231
Etiology, yes/no
HBV	51/25	70/26	0.407
Cirrhosis	23/53	36/60	0.321
Ascites	11/65	6/90	0.073
Laboratory results in U/L
ALT	49 (11-1315)	39 (7-1436)	0.291
AST	50 (16-1075)	40 (11-1493)	0.308
ALP	111 (30-732)	89 (36-867)	0.149
GGT	80 (12-623)	62 (14-914)	0.084
PLT as 109/L	136 (41-370)	117 (3-486)	0.055
PT (INR)	1.06 (0.82-1.63)	1.06 (0.73-1.62)	0.697
AFP, ≥ 200/< 200 ng/mL	38/32	36/50	0.122
Tumor
Size, ≥ 5/< 5 cm	57/19	37/59	< 0.001
Type, multiple/single	18/58	14/82	0.128
Vascular invasion, yes/no	8/68	6/90	0.308
Noninvasive model score
CLIP	1 (0-4)	1 (0-4)	0.027
Pohl, negative/positive	47/39	60/36	0.930
AARP, negative/positive	14/62	11/85	0.198
AAR	1.08 (0.13-3.29)	1.02 (0.09-4.85)	0.826
API	7 (1-10)	7 (2-10)	0.319
CDS	6 (2-9)	6 (3-9)	0.286
APRI	0.90 (0.16-19.71)	0.90 (0.17-55.71)	0.658
FIB-4	2.90 (0.51-17.98)	2.94 (0.40-81.57)	0.384
FibroQ	4.68 (0.48-22.82)	4.49 (0.14-108.25)	0.224
Lok index	0.56 ± 0.23	0.58 ± 0.22	0.600
GUCI	1.04 (0.14-19.32)	0.95 (0.17-83.56)	0.624
APGA	22.95 (6.03-89.35)	19.03 (5.81-92.94)	0.136
PAPAS	3.67 (1.52-9.40)	3.02 (1.67-5.75)	0.136
Survival in mo	23 (5-120)	87 (1-117)	0.003
Death, yes/no	69/7	18/78	< 0.001

AAR: Aspartate aminotransferase/alanine aminotransferase ratio; AARP: AAR-platelet count score; AFP: Alpha-fetoprotein; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; APGA: Aspartate aminotransferase/platelet count/γ-glutamyl transpeptidase/AFP index; API: Age/platelet count index; APRI: Aspartate aminotransferase/platelet count ratio index; AST: Aspartate aminotransferase; CDS: Cirrhosis discriminant score; CLIP: Cancer of the Liver Italian Program; FIB-4: Fibrosis index based on the four factors; FibroQ: Fibro-quotient; GGT: γ-glutamyl transpeptidase; GUCI: Goteburg University Cirrhosis Index; HBV: Hepatitis B virus; INR: International normalized ratio; PAPAS: Platelet count/age/ALP/AFP/AST index; PLT: Platelet count; PT: Prothrombin time. Values are expressed as mean ± SD, median (range), or n.