Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review

Table 1 Quality assessment of selected case series according to the Chambers criteria

Indication for FMT	Author	Year	Publication type (J, CA)	1	2	3	4	5	6	7	8	Case series quality rating
CDI	Aas	2003	J	+	+	+	+	+	-	-	-	Poor
	Arkkila	2010	J	-	+	+	+	+	+	-	-	Poor
	Aroniadis	2013	J	+	-	+	+	+	-	-	-	Poor
	Bansal	2013	J	-	+	-	-	?	-	-	-	Poor
	Bobo	2013	CA	+	-	+	+	+	+	-	-	Poor
	Borody	2013	CA	-	+	+	-	?	-	-	-	Poor
	Bowden	1981	J	-	-	+	+	+	-	-	-	Poor
	Brandt	2012	J	+	+	+	+	+	-	-	-	Poor
	Byrne	2008	CA	+	+	-	-	+	+	-	-	Poor
	Eisman	1958	J	-	-	-	-	-	-	-	-	Poor
	Elopre	2013	J	-	-	-	-	+	-	-	-	Poor
	Fischer	2013	CA	-	-	+	+	+	-	-	+	Poor
	Garborg	2010	J	+	+	-	+	+	-	-	-	Poor
	Hamilton	2012	J	+	+	+	+	+	+	+	+	Good
	Ihunnah	2013	CA	-	-	+	+	-	-	-	-	Poor
	Jorup-Rönström	2012	J	+	+	+	+	+	-	-	-	Poor
	Kassam	2010	CA	-	+	+	+	+	+	+	-	Satisfactory
	Kelly	2012	J	-	+	+	+	+	-	-	-	Poor
	Khanna	2013	CA	+	+	+	-	+	+	-	-	Poor
	Louie	2013	CA	+	-	-	-	-	-	-	-	Poor
	MacConnachie	2009	J	+	+	-	-	+	-	-	-	Poor
	Mattila	2012	J	+	+	+	+	+	-	-	+	Poor
	Mellow	2010	J	-	+	+	+	+	-	-	-	Poor
	Miller	2010	J	-	+	-	-	+	-	-	-	Poor
	Neelakanta	2011	J	-	-	-	+	+	-	-	-	Poor
	Newton	2013	CA	-	-	-	-	-	-	+	-	Poor
	Potakamuri	2013	CA	-	+	+	-	?	-	-	-	Poor
	Rohlke	2010	J	-	+	-	+	+	-	-	-	Poor
	Rubin	2013	J	+	+	+	+	+	-	-	-	Poor
	Shiekh Sroujieh	2012	CA	+	+	+	+	+	+	-	-	Poor
	Silverman	2010	J	-	+	-	-	+	-	-	-	Poor
	Yoon	2010	J	+	+	+	+	+	-	-	-	Poor
	Youngster	2013	CA	+	+	-	+	+	+	-	-	Poor
IBD	Angelberger	2012	J	-	+	-	+	+	+	-	-	Poor
	Borody	2012	CA	-	+	+	+2	+2	-	-	-	Poor
	Greenberg	2013	CA	-	+	+	-1	-1	-	-	+	Poor
	Kump	2013	CA	-	+	-	+	+	+	-	-	Poor
	Kump	2013	J	+	+	+	+	+	+	-	+	Poor
	Kunde	2013	J	+	+	+	+	+	+	-	+/-	Poor
	Vermeire	2012	CA	-	+	+	+	+	+	-	-	Poor
IBS	Pinn	2013	CA	-	-	+	-	+	-	-	-	Poor
Pouchitis	Landy	2013	CA	+	-	+	+	+	+	-	-	Poor
Constipation	Borody	2001	J	-	-	-	-	+	+	-	-	Poor

¹Sixteen out of 21 treated patients were successfully contacted for FU;

²62 patients with FU results were included. Chambers criteria: (1) were selection/eligibility criteria adequately reported? (2) was the selected population representative of that seen in normal practice? (3) was an appropriate measure of variability reported? (4) was loss to follow-up reported or explained? (5) were at least 90% of those included at baseline followed up? (6) were patients recruited prospectively? (7) were patients recruited consecutively? and (8) did the study report relevant prognostic factors? J: Journal article; CA: Conference abstract. ?: Unknown; CDI: Clostridium difficile-infection; IBD: Inflammatory bowel disease; IBS: Irritable bowel syndrome.