Editorial
Copyright ©The Author(s) 2015.
World J Gastroenterol. May 7, 2015; 21(17): 5138-5148
Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5138
Table 1 Summary of studies evaluating DNA methylation in liver fibrosis
Ref.ModelFindings
Komatsu et al[23]Mouse, early fibrosis (2 wk CCl4)global and Spp1 promoter hypomethylation
Tao et al[17]Rat (12 wk CCl4) and HSC-T6 cell line5-aza-2’-deoxycytidine inhibited HSC proliferation and blocked the decreased expressions of RASAL1
Mann et al[24]Rat (5 wk CCl4) HSC and human HSC line5-aza-2’-deoxycytidine blocked HSC transdifferentiation and prevented loss of PPARγ expression
Zeybel et al[12]Human NAFLDPPARγ promoter hypermethylation in severe more than mild fibrosis
Oh et al[25]Human cirrhotic and HCC tissuesIncreased DNMT3a mRNA and hypermeyhylated cell cycle and tumor suppressor genes in cirrhotic but less than in HCC tissues