Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis

Table 3 Meta-analysis results

Comparison	OR	95%CI	P value	Heterogeneity		Effects model
				I2	P value
G vs T	1.18	1.05-1.32	0.0041	71%	< 0.00001	Random
Caucasian	1.09	0.94-1.26	0.24	72%	0.0004	Random
Asian	1.27	1.07-1.51	0.0071	70%	0.003	Random
Colorectal cancer	1.15	0.99-1.33	0.06	73%	< 0.0001	Random
Gastric cancer	1.41	1.09-1.83	0.0091	70%	0.02	Random
Esophageal cancer	1.01	0.88-1.16	0.87	0%	0.40	Fixed
GG vs TT	1.25	0.98-1.59	0.07	73%	< 0.00001	Random
Caucasian	1.04	0.77-1.41	0.81	72%	0.0003	Random
Asian	1.58	1.05-2.38	0.031	76%	0.002	Random
Colorectal cancer	1.12	0.79-1.59	0.51	79%	< 0.00001	Random
Gastric cancer	1.77	1.11-2.84	0.021	63%	0.04	Random
Esophageal cancer	1.02	0.77-1.35	0.90	0%	0.34	Fixed
TG vs TT	1.28	1.08-1.52	0.0041	68%	< 0.0001	Random
Caucasian	1.26	0.98-1.63	0.07	76%	<0.0001	Random
Asian	1.30	1.01-1.67	0.041	63%	0.01	Random
Colorectal cancer	1.23	0.98-1.54	0.08	73%	< 0.0001	Random
Gastric cancer	1.66	1.20-2.31	0.0021	51%	< 0.0001	Random
Esophageal cancer	1.04	0.83-1.31	0.72	0%	0.41	Fixed
GG+TG vs TT	1.32	1.10-1.57	0.0021	73%	< 0.00001	Random
Caucasian	1.24	0.95-1.61	0.11	80%	< 0.00001	Random
Asian	1.38	1.07-1.78	0.011	66%	0.007	Random
Colorectal cancer	1.23	0.98-1.55	0.08	75%	< 0.0001	Random
Gastric cancer	1.77	1.40-2.24	< 0.00011	19%	0.29	Fixed
Esophageal cancer	1.02	0.81-1.29	0.84	9%	0.29	Fixed
GG vs TT+TG	1.10	0.90-1.34	0.33	70%	< 0.0001	Random
Caucasian	0.95	0.75-1.20	0.66	64%	0.004	Random
Asian	1.36	0.95-1.95	0.10	77%	0.002	Random
Colorectal cancer	1.05	0.77-1.43	0.76	79%	< 0.00001	Random
Gastric cancer	1.25	0.99-1.56	0.06	33%	0.21	Fixed
Esophageal cancer	0.96	0.75-1.21	0.71	0%	0.38	Fixed

¹Represent a significant association between APE1 Asp148Glu polymorphism and GI cancer risk in three genetic models in the overall population.