Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

Table 5 Univariate and multivariate analyses of factors associated with tumor recurrence in patients with hepatitis C virus infection

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age	1.001	0.972-1.031	0.950
Sex, male	1.455	0.823-2.570	0.197
Preoperative laboratory values
Aspartate transaminase	1.005	0.999-1.011	0.134
Alanine transaminase	1.003	0.966-1.010	0.412
Platelets	1.015	0.983-1.049	0.363
Serum ALB	0.569	0.297-1.092	0.090
PT	0.999	0.980-1.019	0.943
Serum TBIL	1.281	0.610-2.692	0.513
ICGR15	1.049	1.017-1.081	0.0021	1.069	1.032-1.108	< 0.0011
Tumor markers
HH group	4.427	2.238-8.760	< 0.0011	5.098	2.165-12.005	< 0.0011
HL group	2.210	1.166-4.189	0.0151	2.325	1.077-5.018	0.0321
Intraoperative data
Blood loss	1.001	1.000-1.001	< 0.0011	1.000	0.999-1.000	0.292
Surgical duration	1.003	1.002-1.004	< 0.0011	1.002	0.998-1.006	0.129
Pathologic results
Tumor size	1.290	1.178-1.413	< 0.0011	1.160	1.033-1.302	0.0121
Multiple tumors	1.264	1.073-1.487	0.0051	1.264	1.041-1.534	0.0181
Vascular invasion	2.454	1.479-4.071	0.0011	1.597	0.890-2.867	0.117

¹Represents statistical significance. HH group: Alpha-fetoprotein values > 21.0 ng/mL and des-gamma-carboxy prothrombin values > 67 mAU/mL; HL group: Alpha-fetoprotein values > 21.0 ng/mL or des-gamma-carboxy prothrombin values > 67 mAU/mL. ALB: Albumin; PT: Prothrombin; TBIL: Total bilirubin; ICGR15: Indocyanine green retention rate at 15 min.