MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer

Figure 2 MiR-19a promotes the proliferation of gastric cancer cells and regulates migration and invasion in gastric cancer. A, B: Expression of miR-19a mRNA in SGC-7901 cells transfected with miR-19a mimic/inhibitor vector (indicated as pre-miR-19a and miR-19a inh) or nagetive control vector (indicated as pre-NC and NC-inh); C: Cell proliferation assay of SGC-7901 cells transfected with miR-19a mimic/inhibitor vector. The OD values are measured each day at the same time point. Data are expressed as mean ± SD from three experiments; D: Representative images of migrated cells on transwell plates that were originally plated with 10⁵ cells. MiR-19a precursors or inhibitors regulate gastric cancer SGC7901 and NUGC-3 cell migration relative to NC group (t-test); E: Representative images showing cells that invaded through transwell and the numbers of invaded cells. MiR-19a precursors or inhibitors regulate gastric cancer SGC7901 and NUGC-3 cell invasion relative to NC group (t test). Each experiment was repeated at least three times. Error bars correspond to the mean ± SD.