Clinical literature review of 1858 Crohn's disease cases requiring surgery in China

Table 4 Summary of the clinical characteristics of Groups A and B n (%)

Surgery characteristics	Group A(n = 447)	Group B(n = 620)	P value
Gender ratio (male/female)	262/185	375/245	0.539
Mean age	38.46	37.78	-
Disease location1			< 0.001
L1	166 (53.21)	126 (29.37)	< 0.001
L2	82 (26.28)	111 (25.87)	0.901
L3	54 (17.31)	179 (41.72)	< 0.001
Upper gastrointestinal disorder involvement	10 (3.21)	13 (3.03)	0.892
Surgical indication			< 0.001
Intestinal obstruction or stricture	92 (20.58)	205 (33.06)	< 0.001
Abdominal mass	44 (9.84)	36 (5.81)	0.013
Perianal disease	0 (0.00)	97 (15.65)	< 0.001
Intestinal fistulae	7 (1.57)	68 (10.97)	< 0.001
Intestinal adhesion	0 (0.00)	12 (1.94)	0.003
Gastrointestinal bleeding	2 (0.45)	26 (4.19)	< 0.001
Abdominal abscess	11 (2.46)	30 (4.84)	0.046
Intestinal perforation	22 (4.92)	46 (7.42)	0.099
Peritonitis or other acute abdominal diseases	21 (4.70)	17 (2.74)	0.089
Failure of drug therapy	248 (55.48)	83 (13.39)	< 0.001
Diagnosis of CD before surgery			< 0.001
Certain	137 (30.65)	194 (31.29)	0.689
Misdiagnosis2	156 (34.90)	75 (12.10)	< 0.001
Intestinal tuberculosis	22 (14.10)	2 (2.67)	0.008
UC	8 (5.13)	6 (8.00)	0.574
Tumor	49 (31.41)	23 (30.67)	0.909
Acute appendicitis	77 (49.36)	44 (58.67)	0.185
Uncertain	154 (34.45)	351 (56.61)	< 0.001
Surgical procedure
Bowel resection	312 (69.80)	430 (69.35)	0.876
Colonic resection	83 (18.57)	105 (16.94)	-
Ileal resection	65 (14.54)	175 (28.23)	-
Ileocolonic resection	40 (8.95)	105 (16.94)	-
Upper gastrointestinal resection	8 (1.79)	1 (0.16)	-
Unclassified bowel resection	126 (28.19)	44 (7.10)	-
Operation for perianal disease	0 (0.00)	81 (13.06)	< 0.001
Ileostomy or colostomy	6 (1.34)	27 (4.35)	0.005
Stricturoplasty	1 (0.22)	8 (1.29)	0.123
Complication of surgery3	68 (18.94)	133 (24.23)	0.061
Infection	21 (30.88)	60 (45.11)	0.052
Stricture or stenosis	14 (20.59)	24 (18.05)	0.663
Death	16 (23.53)	7 (5.26)	0.708
Intestinal fistulae	9 (13.24)	28 (21.05)	< 0.001
Abdominal abscess	5 (7.35)	5 (3.76)	0.176
Surgical relapse rate4	115 (31.59)	126 (28.64)	0.362
Surgery after relapse	38 (33.04)	34 (26.98)	0.305

¹There were 312 cases and 429 cases for which the disease location was reported in Groups A and B, respectively;

²Misdiagnosis was retrospectively analyzed furtherly;

³There were 359 cases and 549 cases in Groups A and B, respectively, who experienced surgical complications; the distribution of these complications was further analyzed;

⁴There were 364 cases and 440 cases in Group A and B, respectively, which contained follow-up data. P < 0.05 was considered to be significant. L1: Small intestine; L2: Colon; L3: Small intestine and colon; UC: Ulcerative colitis.