Individual having a parent with early-onset gastric cancer may need screening at younger age

Table 2 Age at diagnosis and clincopathologic characteristics of patients with gastric cancer according to affected first-degree family member n (%)

	Father	Mother	Sibling	P value
	n = 349 (37.8%)	n = 229 (24.8%)	n = 319 (34.5%)	Father vs mother	Father vs sibling	Mother vs sibling
Age at diagnosis, yr (mean ± SD)	54.4 ± 10.4	57.2 ± 10.0	62.2 ± 9.8	0.0021	< 0.0011	< 0.0011
Male	252 (72.2)	137 (59.8)	213 (66.8)	0.0022	0.1272	0.0952
Female	97 (27.8)	92 (40.2)	106 (33.2)
Tumor diameter (mean ± SD)	3.9 ± 2.8	3.9 ± 2.4	3.8 ± 2.4	0.9881	0.6611	0.6611
Lauren’s classification				0.7642	0.0032	0.0212
Intestinal	191 (54.7)	132 (57.6)	205 (64.3)
Diffuse	130 (37.3)	81 (35.4)	80 (25.1)
Mixed	28 (8.0)	16 (7.0)	34 (10.7)
H. pylori infection status				0.5302	0.5192	0.8272
Current	241 (69.1)	150 (65.5)	206 (64.6)
Past	43 (12.3)	25 (10.9)	42 (13.2)
Negative	37 (10.6)	32 (14.0)	45 (14.1)
Not available	28 (8.0)	22 (9.6)	26 (8.2)
Gastric cancer stage				0.1932	0.7462	0.1862
Stage 1	254 (72.8)	166 (72.5)	235 (73.7)
Stage 2	41 (11.7)	28 (12.2)	43 (13.5)
Stage 3	35 (10.0)	30 (13.1)	27 (8.5)
Stage 4	19 (5.4)	5 (2.2)	14 (4.4)

¹Independent t-test;

²χ² test. H. pylori: Helicobacter pylori.