Individual having a parent with early-onset gastric cancer may need screening at younger age

Table 1 Clinicopathologic characteristics of patients with or without a first-degree family history of gastric cancer n (%)

	Total (4282)	With first-degree family history	Without first-degree family history
		n = 924 (21.6%)	n = 3358 (78.4%)	P value
Age at diagnosis, yr (mean ± SD)	58.0 ± 11.8	58.0 ± 10.7	58.1 ± 12.0	0.8971
Male	2886 (67.4)	620 (67.1)	2266 (67.5)	0.8271
Female	1396 (32.6)	304 (32.9)	1092 (32.5)
Tumor diameter (mean ± SD)	4.0 ± 2.7	3.8 ± 2.6	4.2 ± 2.8	0.0041
Lauren’s classification				< 0.0012
Intestinal	2251 (52.6)	544 (58.9)	1707 (50.8)
Diffuse	1642 (38.3)	300 (32.5)	1342 (40.0)
Mixed	389 (9.1)	80 (8.6)	309 (9.2)
H. pylori infection status				0.1742
Current	2851 (66.6)	612 (66.2)	2239 (66.7)
Past	622 (14.5)	114 (12.3)	508 (15.1)
Negative	536 (12.5)	119 (12.9)	417 (12.4)
Not available	273 (6.4)	79 (8.5)	194 (5.8)
GC stage				0.0812
Stage 1	3009 (70.3)	679 (73.5)	2330 (69.4)
Stage 2	568 (13.3)	114 (12.3)	454 (13.5)
Stage 3	476 (11.1)	92 (10.0)	384 (11.4)
Stage 4	229 (5.3)	39 (4.2)	190 (5.7)

¹Independent t-test;

²χ² test. SD: Standard deviation; GC: Gastric cancer; H. pylori: Helicobacter pylori.