Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population

Table 5 Haplotype analysis of polymorphisms

Haplotype1	Frequency		χ2	P value	OR	95%CI
	HBV infection	Control
A-T-A	0.150	0.127	1.117	0.291	1.209	0.850-1.720
G-C-G	0.137	0.103	2.725	0.099	1.376	0.941-2.011
G-T-A	0.283	0.31	0.883	0.347	0.882	0.678-1.147
G-T-G	0.429	0.459	0.959	0.327	0.886	0.695-1.129
	HCC	non-HCC
A-T-A	0.165	0.104	4.057	0.044	1.700	1.010-2.863
G-C-G	0.138	0.133	0.017	0.900	1.033	0.635-1.681
G-T-A	0.267	0.333	3.226	0.072	0.072	0.503-1.031
G-T-G	0.430	0.423	0.009	0.926	1.016	0.726-1.422

¹Haplotype of rs13143866 (G/A), rs2221903 (T/C), and rs907715 (G/A). HBV: Hepatitis B virus; HCC: Chronic HBV-infected patients with hepatocellular carcinoma; non-HCC: Chronic HBV-infected patients without hepatocellular carcinoma.