Field cancerisation in colorectal cancer: A new frontier or pastures past?

doi:10.3748/wjg.v21.i13.3763

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Apr 7, 2015 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2015; 21(13): 3763-3772
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3763

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Figure 2 Changes in crypt morphology, cellular ultrastructure and epigenetic modulation in the field defect. A, B: Changes in crypt morphology characterised by increased branching and distension of crypts, increased cell division and a change in proportion of cells with increase in goblet cells; C, D: Changes in the cell cytoskeleton, organelles and nuclear composition; E, F: Epigenetic modulation of DNA leading to transcriptional silencing of certain genes involved in regulation of cell division, apoptosis and DNA repair.

Citation: Patel A, Tripathi G, Gopalakrishnan K, Williams N, Arasaradnam RP. Field cancerisation in colorectal cancer: A new frontier or pastures past? World J Gastroenterol 2015; 21(13): 3763-3772
URL: https://www.wjgnet.com/1007-9327/full/v21/i13/3763.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i13.3763