Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma

Table 2 Survival status and clinicopathological parameters in 90 hepatocellular carcinoma speciments

Parameters	Total	Survival Status		P value	χ2value
		Dead	Alive
		n = 43	n = 47
Age (yr)
< 45	33	16	17	0.919	0.010
≥ 45	57	27	30
Gender
Male	57	26	31	0.589	0.292
Female	33	17	16
Serum AFP level (ug/mL)
< 25	34	15	19	0.588	0.293
≥ 25	56	28	28
Cirrhosis
No	26	13	13	0.788	0.072
Yes	64	30	34
No. of tumor nodes
Single	51	23	28	0.561	0.339
Multiple	39	20	19
HBV
Negative	43	14	29	0.006	7.644
Positive	47	29	18
Maximal tumor size (cm)
< 4.5	39	7	32	< 0.051	24.543
≥ 4.5	51	36	15
Tumor metastasis
No	77	36	41	0.636	0.224
Yes	13	7	6
Microvascular invasion
No	66	31	35	0.799	0.065
Yes	24	12	12
Histological grade
I-II	49	14	35	< 0.051	15.902
III-IV	41	29	12
Stat4 expression
Low	40	6	34	< 0.051	31.003
High	50	37	13
Ki67 expression
Low	49	10	39	< 0.051	32.293
High	41	33	8

¹The P value was considered significant. Statistical analyses were performed using Pearson χ² test. HBV: Hepatitis B virus.