Differentiation of acute and chronic hepatitis B in IgM anti-HBc positive patients

Table 3 Diagnostic performance of laboratory tests for acute hepatitis B

	Sensitivity	Specificity	PPV	NPV
IgM anti-HBc (S/Co)
≥ 7	98.1	82.8	91.2	96.0
≥ 8	96.2	89.7	94.4	92.9
≥ 9	94.3	86.2	92.6	89.3
HBV DNA (log10 IU/mL)
< 5	56.6	86.2	88.2	52.1
< 5.5	81.1	72.4	84.3	67.7
< 6	83.0	65.5	81.5	67.9
Combination1	98.1	86.2	92.7	92.6

¹Combination obtained from variable 0.2303*IgM anti-HBc-1.0694*Log HBV-DNA. The values are expressed in percent. PPV: Positive predictive value; NPV: Negative predictive value; IgM anti-HBc: Immunoglobulin M antibody to hepatitis B core antigen; S/CO: Sample to the cutoff value; HBV: Hepatitis B virus.