Differentiation of acute and chronic hepatitis B in IgM anti-HBc positive patients

Table 1 Comparison clinical features between acute hepatitis B and chronic hepatitis B with acute exacerbation

Variables	Total (n = 82)	AHB (n = 53)	CHB-AE (n = 29)	P value
Age (yr)1	41.9 ± 12.7	40.2 ± 13.4	45.0 ± 11.0	0.023
Sex (male, %)	52 (63.4%)	30 (56.6%)	22 (75.9%)	0.098
WBC (× 103/μL)1	6.0 ± 1.9	6.1 ± 2.1	5.9 ± 1.6	0.808
Hb (g/dL)1	14.0 ± 1.7	13.9 ± 1.8	14.2 ± 1.7	0.782
Platelet (× 103/μL)1	212.1 ± 84.3	232.8 ± 85.9	174.3 ± 67.4	0.001
ALT (IU/L)1	1864.2 ± 1397.2	2273.2 ± 1373.1	1116.8 ± 1118.3	< 0.001
Total bilirubin (mg/dL)1	6.2 ± 5.6	7.0 ± 4.6	4.7 ± 7.0	< 0.001
Albumin (g/dL)1	3.5 ± 0.5	3.6 ± 0.5	3.4 ± 0.5	0.151
INR1	1.4 ± 0.9	1.5 ± 1.1	1.3 ± 0.5	0.861
HBeAg positivity (+, %)2	53 (64.6%)	31 (60.8%)	22 (75.9%)	0.226
HBeAg titer (S/CO)1	133.5 ± 261.5	49.2 ± 60.9	415.7 ± 367.8	0.001
IgM anti-HBc titer (S/CO)1	16.4 ± 10.7	22.3 ± 7.1	6.0 ± 6.9	< 0.001
HBV DNA (log10 IU/mL)1	5.3 ± 1.8	4.5 ± 1.6	6.7 ± 1.4	< 0.001

¹Mean ± SD;

²HBeAg was not checked in two patients of AHB group. AHB: Acute hepatitis B; CHB-AE: Chronic hepatitis B with acute exacerbation; WBC: White blood cell; Hb: Hemoglobin; ALT: Alanine aminotransferase; INR: International normalized ratio; HBeAg: hepatitis B e antigen; IgM anti-HBc: Immunoglobulin M antibody to hepatitis B core antigen; S/CO: Sample/cutoff value; HBV: Hepatitis B virus.