Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: A systematic review and meta-analysis

Table 2 Basic surgical characteristics of patients in the included studies

Ref.	Arm	Operative time (min)	Blood loss (mL)	Surgical procedure
Sato et al[19]	SSH	357 ± 58	615 ± 268	Extensive resection including lymph node dissection
	Saline	326 ± 23	712 ± 184
Akamoto et al[20]	SSH	496 ± 140	1 672 ± 426	Esophagectomy and esophagogastric anastomosis
	Saline	569 ± 46	1 339 ± 316
Kawahara et al[22]	SSH	517 (range 443-733)	305 (range 180-1050)	Video-assisted thoracoscopic oesophagectomy
	Saline	549 (range 453-785)	32 (range 150-1910)
Makino et al[24]	SSH	433 (95%CI: 399-467)	468 (95%CI: 380-556)	Video-assisted thoracoscopic oesophagectomy
	Saline	431 (95%CI: 407-455)	514 (95%CI: 386-643)
Yamaguchi et al[29]	SSH	387 ± 57	488 ± 229	Right-sided transthoracic esophagectomy with cervical esophagogastrostomy and lymph node dissection
	Saline	363 ± 85	376 ± 166
Iwahashi et al[21]	SSH	491 ± 62	422 ± 210	Radical esophagectomy with a two- or three-field lymph node dissection via a cervicothoracoabdominal approach
	SSH	466 ± 72	405 ± 262
	Control	482 ± 69	430 ± 173
Yamaki et al[30]	SSH	538 ± 121	969 ± 505	Radical esophagectomy
	Control	552 ± 157	1134 ± 682
Ono et al[28]	SSH	573.4 ± 72.6	1685.1 ± 1255.3	Esophagectomy and reconstruction with gastric mobilization by right posterolateral thoracotomy and laparotomy
	Control	568.7 ± 164.1	1032.4 ± 347.7
Suda et al[14]	SSH	458 (95%CI: 373-545)	361 (95%CI: 218-682)	Transthoracic esophagectomy
	Control	626 (95%CI: 541-700)	520 (95%CI: 216-700)
Kobayashi et al[23]	SSH	311 ± 66	359 ± 253	Thoracoscopy-assisted subtotal esophagectomy
	Control	412 ± 71	402 ± 161
Mimatsu et al[25]	SSH	407.3 ± 74.6	346.7 ± 122.2	Transthoracic esophagectomy with reconstruction of the stomach role via the posterior sternum
	Control	396.7 ± 96.3	354.4 ± 134.5
Nishiyama et al[27]	SSH	450.2 ± 64.1	813.6 ± 548.4	Thoracolaparotomic total thoracic esophagectomy, chest wall-antral stomach reconstruction, and 3-regional lymph node dissection
	Control	445.8 ± 87.9	735.2 ± 479.0
Nagai et al[26]	SSH	576.4 ± 126.7	630.1 ± 392.0	Subtotal esophagectomy and reconstruction through a right posterolateral thoracotomy and upper midline laparotomy
	Control	537.3 ± 120.2	494.2 ± 312.7

SSH: Sivelestat sodium hydrate.