Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas

doi:10.3748/wjg.v21.i12.3472

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2015; 21(12): 3472-3479
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3472

Table 2 Pathological findings in patients with lymphoepithelioma-like-hepatic carcinomas

		LEL-HCC (n = 29)	LEL-ICC (n = 24)
Histological features
	Poorly differentiated	16/29	10/24
	Moderately differentiated	13/29	3/24
	Combined LEL-HCC and HCC	None
	Combined LEL-ICC and ICC		9/24
Immunohistology
	HepPAR1	3/3	1/2
	CK7 and CK19	4/11	24/24
	EpCAM	ND	7/7
	CD133	ND	7/7
EBV status
	EBERs	3/18	17/24
	LMP1/2 antigens	ND	0/8
	LMP1 gene	ND	2/2
	EBNA2	ND	1/1
Lymphoid infiltration
	CD3/CD20 ratio > 1	29/29	4/4
	CD4/CD8 ratio < 1	11/29	1/4

LEL-HCC: Lymphoepithelioma-like hepatocellular carcinomas; LEL-ICC: Lymphoepithelioma-like cholangiocarcinomas; EBV: Epstein-Barr virus; EBERs: EBV-encoded RNAs; LMP: Latent membrane protein; EBNA2: Epstein Barr nuclear antigen 2; ND: Not done.

Citation: Solinas A, Calvisi DF. Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas. World J Gastroenterol 2015; 21(12): 3472-3479
URL: https://www.wjgnet.com/1007-9327/full/v21/i12/3472.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i12.3472