Genome-based nutrition: An intervention strategy for the prevention and treatment of obesity and nonalcoholic steatohepatitis

Table 1 Allelic frequencies of nutrient-interacting genes in America and worldwide

Gene	Allele	Population	Frequency (%)	Ref.
MTHFR	677T	Huicholes (Native Mexican)	56.0	Dávalos et al[28] 2000
		Asian	36.7	HapMap-JPT[29]
		European	23.7	HapMap-CEU[29]
		African	11	HapMap-YRI[29]
TAS2R38	AVI	European	47	Kim et al[30] 2003
		Asian	30
	PAV	Southwest Native American	100
		Asian	70
		European	49
AMY1	Copy number	European-American (high starch diet)	6.81	Perry et al[31] 2007
		Mexican (high starch diet)	6.11	Mejía-Benítez et al[32] 2014
		Biaka African (low starch diet)	5.471	Perry et al[31] 2007
		Yakut Asian (low starch diet)	5.241
CD36	-31118A	Egyptian	67.5	Bayoumy et al[33] 2012
		Caucasian	53.6	Ma et al[34] 2004
		African American	43.8	Keller et al[35] 2012
		North Indian	38.2	Banerjee et al[36] 2010
ABCA1	230C	Xavantes (Native Brazilian)	31	Acuña-Alonzo et al[37] 2010
		Coras (Native Mexican)	29
		European	0
		Asian	0
		African	0
APOE	E2	African	19	Singh et al[38] 2006
		European	12.7
		Asian	4.6
		Huicholes (Native Mexican)	0
	E4	Huicholes (Native Mexican)	28.7	Aceves et al[39] 2006
		African	27	Singh et al[38] 2006
		Asian	10.5
		European	1.1
LCT	-13910T	European	39.1	Corella et al[40] 2010
		White Brazilian	24.7	Mattar et al[41] 2009
		Mapuches (Native Chilean)	22.2	Morales et al[42] 2011
		Black Brazilian	12	Mattar et al[41] 2009

¹Mean copy number.