Basic Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Mar 21, 2015; 21(11): 3256-3265
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3256
Table 1 Association of high-mobility group box 1 and vascular endothelial growth factor with clinicopathologic parameters in patients with intrahepatic cholangiocarcinoma n (%)
ParametersHMGB1
P valueVEGF-C
P value
LowHighLowHigh
Age (yr)
< 6018 (42.9)24 (57.1)25 (59.5)17 (40.5)
≥ 609 (39.1)14 (60.9)0.77110 (43.5)13 (56.5)0.056
Gender
Male15 (46.9)17 (63.6)15 (46.9)17 (53.1)
Female12 (36.4)21 (63.6)0.39018 (54.5)15 (45.5)0.536
Tumor size (cm)
< 58 (36.4)14 (63.6)10 (45.5)12 (54.5)
≥ 519 (44.2)24 (55.8)0.54523 (53.5)20 (46.5)0.540
Histologic classification
Well8 (47.1)9 (52.9)12 (70.6)5 (29.4)
Moderate10 (32.3)21 (67.7)10 (32.3)21 (67.7)
Poor9 (52.9)8 (47.1)0.32912 (70.6)5 (29.4)0.016
Tumor stage
I + II21 (41.2)30 (8.8)25 (49.0)26 (51.0)
III + IV6 (42.9)8 (57.1)0.9108 (57.1)6 (42.9)0.590
Node stage
Negative25 (50)25 (50)30 (60.0)20 (40.0)
Positive2 (13.3)13 (86.7)0.0113 (20.0)12 (80.0)0.007
UICC stage
I + II18 (48.6)19 (51.4)21 (56.8)16 (43.2)
III + IV9 (32.1)19 (67.9)0.18112 (42.9)16 (57.1)0.267
Microvascular invasion
Negative20 (39.2)31 (60.8)26 (51.0)25 (49.0)
Positive7 (50.0)7 (50.0)0.4587 (50.0)7 (50.0)0.948
Perineural invasion
Negative22 (38.6)35 (61.4)30 (52.6)27 (47.4)
Positive5 (62.5)3 (37.5)0.26013 (37.5)5 (62.5)0.475a
Satellite nodular
Negative24 (44.4)30 (55.6)27 (50)27 (50)
Positive3 (27.3)8 (72.7)0.2926 (54.5)5 (45.5)0.783
HBV infection
Negative24 (42.1)33 (57.9)30 (52.6)27 (47.4)
Positive3 (37.5)5 (62.5)1.00013 (37.5)5 (62.5)0.475a
Calculus
Negative23 (40.4)34 (59.6)29 (51.8)27 (48.2)
Positive4 (50.0)4 (50.0)0.71213 (37.5)5 (62.5)0.708a
LMVD
Low15 (57.7)11 (42.3)18 (69.2)8 (30.8)
High12 (30.8)27 (9.2)0.03115 (38.5)24 (61.5)0.015