Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics

doi:10.3748/wjg.v21.i1.60

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jan 7, 2015; 21(1): 60-83
Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.60

Table 4 Subdivision of autoimmune hepatitis according to the autoantibodies detected

Types of AIH	Characteristic autoantibodies
AIH-1	ANA, SMA, p-ANCA (p-ANNA), anti-ASGP-R, anti-SLA/LP (specific antibody; molecular target: SepSecS)
AIH-2	Anti-LKM1 (molecular target: CYP2D6), anti-LKM3 (molecular target: UGT1), anti-LC1 (liver specific antibody, molecular target: FTCD), anti-ASGP-R
AIH as component of APECED	ANA, anti-LC (molecular target: unknown), anti-LKM (molecular target: CYP2A6, CYP1A1, CYP2B6), anti-LM (liver specific antibody; molecular target: CYP1A2)

AIH-1: Autoimmune hepatitis type 1; AIH-2: Autoimmune hepatitis type 2; APECED: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; ANA: Antinuclear antibodies; SMA: Smooth muscle antibodies; p-ANCA: Perinuclear antineutrophil cytoplasmic antibodies; p-ANNA: Peripheral antineutrophil nuclear antibodies; Anti-ASGP-R: Antibodies against asialoglycoprotein receptor; Anti-SLA/LP: Antibodies against soluble liver antigen/liver pancreas; SEpSEcS: Synthase-converting O-phosphoseryl-tRNA to selenocysteinyl-tRNA; anti-LKM1: Anti-liver kidney microsomal antibodies type 1; CYP2D6: Cytochrome P450 2D6; Anti-LKM3: Anti-liver kidney microsomal antibodies type 3; UGT1: UDP-glucuronosyltransferases; Anti-LC1: Anti-liver cytosol antibodies type 1; FTCD: Formiminotransferase cyclodeaminase; CYP2A6: Cytochrome P450 2A6; CYP1A1: Cytochrome P450 1A1; CYP2B6: Cytochrome P450 2B6; Anti-LM: Antibodies against liver membrane; CYP1A2: Cytochrome P450 1A2.

Citation: Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN. Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics. World J Gastroenterol 2015; 21(1): 60-83
URL: https://www.wjgnet.com/1007-9327/full/v21/i1/60.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i1.60