Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies

Table 6 Incidence of adverse drug reactions n (%)

	PAC	PAM	Sequential	Concomitant	P value1
	(n = 170)	(n = 170)	(n = 170)	(n = 170)
Patients with side effect	86 (50.6)	82 (48.2)	70 (41.2)	69 (40.6)	0.158
	(43.07, 58.10)	(40.72, 55.75)	(33.78, 48.57)	(33.21, 47.97)
Total side effects (n)	101	93	83	96
Side effect
Abdominal bloating	2 (1.18)	5 (2.94)	0 (0.00)	0 (0.00)	7 (1.03)
Abdominal pain	8 (4.71)	11 (6.47)	0 (0.00)	0 (0.00)	19 (2.79)
Bitter taste	28 (16.47)	10 (5.88)	11 (6.47)	16 (9.41)	65 (9.56)
Constipation	0 (0.00)	6 (3.53)	0 (0.00)	1 (0.59)	7 (1.03)
Dizziness	4 (2.35)	3 (1.76)	3 (1.76)	1 (0.59)	11 (1.62)
Dyspepsia	5 (2.94)	15 (8.82)	13 (7.65)	13 (7.65)	46 (6.76)
Epigastric pain	6 (3.53)	0 (0.00)	11 (6.47)	21 (12.35)	38 (5.59)
General weakness	2 (1.18)	3 (1.76)	2 (1.18)	2 (1.18)	9 (1.32)
Halitosis	0 (0.00)	0 (0.00)	1 (0.59)	1 (0.59)	2 (0.29)
Headache	4 (2.35)	3 (1.76)	3 (1.76)	4 (2.35)	14 (2.06)
Loose stool	24 (14.12)	2 (1.18)	17 (10.00)	19 (11.18)	62 (9.12)
Loss of appetite	6 (3.53)	3 (1.76)	1 (0.59)	0 (0.00)	10 (1.47)
Nausea	12 (7.06)	32 (18.82)	20 (11.76)	15 (8.82)	79 (11.62)
Oral ulcer	0 (0.00)	0 (0.00)	1 (0.59)	0 (0.00)	1 (0.15)
Skin eruption	0 (0.00)	0 (0.00)	1 (0.59)	0 (0.00)	1 (0.15)
Sleeping tendency	0 (0.00)	0 (0.00)	0 (0.00)	1 (0.59)	1 (0.15)
Vomiting	0 (0.00)	0 (0.00)	3 (1.76)	3 (1.76)	6 (0.88)

¹P-value of χ² test. PAC: Rabeprazole, amoxicillin, clarithromycin; PAM: Rabeprazole, amoxicillin, metronidazole.