Screening and early detection of pancreatic cancer in high risk population

Table 1 High risk population and the estimated risk for pancreatic cancer

Syndrome	Gene	RR	Lifetime risk
Peutz-Jeghers syndrome	STK11/LKB1	132	36% by age 65 yr
Hereditary pancreatitis	PRSS1	53	Male: 11% and 49% by age 50 and 75 yr
			Female: 8% and 55% by age 50 and 75 yr
FAMMM	p16	13-22	16% lifetime risk
Familial breast and ovarian	BRCA1/2	3-10	5% lifetime risk
HNPCC	MLH1, MSH6, MSH2, PMS2	1.5-9	8.6% lifetime risk
Familial pancreatic cancer
2 FDR	Unknown	6.4	8%-12% lifetime risk
3 FDR	Unknown	32	40% lifetime risk

FDR: First degree relative; HNPCC: Hereditary non-polyposis colorectal cancer; PRSS1: Cationic trypsinogen gene; FAMMM: Familial atypical multiple mole melanoma syndrome.