Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

doi:10.3748/wjg.v20.i9.2279

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2014; 20(9): 2279-2303
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2279

Table 5 Lipogenic enzyme inhibitors that can be used as potential antitumor drugs

Enzyme name	Inhibitor	Type of neoplasm	Ref.
Fatty acid synthase (FASN)	Cerulenin	Breast cancer,	[303]
	Cerulenin	ovarian cancer	[304]
	C75	Breast cancer	[216]
	C75	Pancreatic cancer	[232]
	Epigallocatechin-3-gallate (EGG)	Prostate cancer	[228]
	C93	Lung cancer	[305]
	C93	Ovarian cancer	[306]
	Luteolin	Breast cancer, ovarian cancer	[228]
	Luteolin	Pancreatic cancer	[232]
	Orlistat	Prostate cancer	[307]
ATP citrate lyase (ACLY)	SB-204990 hydroxycitrate	Lung cancer	[308]
		Brest cancer	[18]
		Pancreatic cancer	[101]
Acetyl-CoA carboxylase (ACCA)	Soraphen A TOFA	Prostate cancer	[309]
Acetyl-CoA carboxylase (ACCA)	Soraphen A TOFA	Lung cancer, colon cancer	[310]
Stearoyl-CoA desaturase (SCD1)	CVT-11127 TOFA	Lung cancer	[222]
Stearoyl-CoA desaturase (SCD1)	CVT-11127 TOFA	Colon cancer	[225]
Acetyl-CoA synthetase (ACS)	Triacsin c	Various cancers cell lines	[311]

Citation: Swierczynski J, Hebanowska A, Sledzinski T. Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J Gastroenterol 2014; 20(9): 2279-2303
URL: https://www.wjgnet.com/1007-9327/full/v20/i9/2279.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i9.2279